Search results for "production [top]"
showing 10 items of 128 documents
Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production of Interleukin-4
2007
A novel paradigm in tumor biology suggests that cancer growth is driven by stem-like cells within a tumor. Here, we describe the identification and characterization of such cells from colon carcinomas using the stem cell marker CD133 that accounts around 2% of the cells in human colon cancer. The CD133(+) cells grow in vitro as undifferentiated tumor spheroids, and they are both necessary and sufficient to initiate tumor growth in immunodeficient mice. Xenografts resemble the original human tumor maintaining the rare subpopulation of tumorigenic CD133(+) cells. Further analysis revealed that the CD133(+) cells produce and utilize IL-4 to protect themselves from apoptosis. Consistently, trea…
Failures (with some successes) of assisted reproduction and gamete donation programs
2013
Although the possibilities for the treatment of infertility have been improved tremendously, not every couple will be treated successfully.Crude overall pregnancy rates of 50-65% per patient can be achieved nowadays, irrespective of the type of profertility treatment applied first.IVF only accounts for about 20% of the pregnancies achieved. Dropout is an important reason for not reaching the estimated pregnancy rate. Even after failed IVF, spontaneous pregnancies do occur. Sperm and oocyte donation (OD) offer additional chances to subfertile couples. Severity of the male factor (in sperm donation) and young donor age (in OD) are important determinants of success.Analysis of assisted reprodu…
Labour Scheduling at an Airport Refuelling Installation
1999
We have developed an automatic assignment procedure for labour scheduling at a continously operating airport refuelling installation. Different types of workers are subject to different conditions on the shifts they can do (morning, evening or night), shift lengths, days-off, holidays, terms of contract and working hours. The scheduling process is carried out on a weekly basis, but there are mid-term and long-term conditions and objectives which link each week with the preceding and following weeks. Our package uses firstly a tabu search algorithm to find the best schemes of shifts/days-off to be used to cover the requirements. Secondly, an assignment problem is solved to match the schemes …
Influence of short-term aging on mechanical properties and morphology of polymer-modified bitumen with recycled plastics from waste materials
2020
Polymer-modified bitumen (PMB) is bitumen that has been specifically engineered with polymer for providing enhanced performance in service. The aging of bitumen is a main aspect that is able to affect its final performance: during the production phase in a hot mix plant, all the binders experience short-term aging due to the high processing temperature. The same is true during the production of the modified binder, when the polymer is dispersed at high temperature in the bitumen mass. This paper aims at studying the effect of short-term aging when using different types of modifiers such as recycled polymers obtained from waste materials. A 50/70 penetration-grade bitumen has been modified, …
Stochastic Scheduling of Production Orders Under Uncertainty
2017
This paper attempts to solve the problem of searching minimum production order completion time variants by means of stochastic logical structures with all cost curve descent points and corresponding minimum-cost schedules. The analysis presented in this paper considers scheduling of unique and small batch production, predominantly to order, which accounts for changing requirements of the customer, the complexity and long production process makespan including its technical preparation. Scheduling of production order was performed by means of GAN networks and employed the concept of soft relations. The cost/time relation analysis is based on two-node network models using the cost curve. A new…
Data-Driven Pump Scheduling for Cost Minimization in Water Networks
2021
Pumps consume a significant amount of energy in a water distribution network (WDN). With the emergence of dynamic energy cost, the pump scheduling as per user demand is a computationally challenging task. Computing the decision variables of pump scheduling relies over mixed integer optimization (MIO) formulations. However, MIO formulations are NP-hard in general and solving such problems is inefficient in terms of computation time and memory. Moreover, the computational complexity of solving such MIO formulations increases exponentially with the size of the WDN. As an alternative, we propose a data-driven approach to estimate the decision variables of pump scheduling using deep neural netwo…
A hierarchic approach to production planning and scheduling of a flexible manufacturing system
1999
Abstract The paper deals with the problem of improving the machine utilization of a flexible manufacturing cell. Limited tool magazine space of the machines turns out to be a relevant bottleneck. A hierarchic approach for this problem is proposed. At the upper level, sets of parts that can be concurrently processed (batches) are determined. At the lower levels, batches are sequenced, linked, and scheduled. Methods taken from the literature are used for the solution of the latter subproblems, and an original mixed integer programming model is formulated to determine batches. The proposed methods are discussed on the basis of computational experience carried out on real instances.
Scheduling in a continuous galvanizing line
2009
In this paper we address a sequencing problem in a Continuous Galvanizing Line of a Spanish Steel Company. Production scheduling in this context is an extremely complex task which needs to take into account many constraints. We present a conceptually simple model and a Tabu Search (TS) algorithm that efficiently solves it. The TS moves are defined in order to repair non-satisfied constraints, leading to smaller and more efficient neighbourhoods. The TS co-ordinates several intensification and diversification procedures guided by an evaluation function based on a shifting penalty strategy. This function reinforces the anticycling mechanism and makes the algorithm avoid already visited soluti…
A heuristic to schedule flexible job-shop in a glass factory
2005
We describe the design and implementation of a scheduling system in a glass factory. The factory produces a large variety of manufactured glass objects in a complex process ranging from melting the glass in the furnaces and blowing it automatically or manually to decorating, assembling and packing it. The structure basically corresponds to a flexible job-shop scheduling problem with some special characteristics. On the one hand, dealing with hot liquid glass imposes no-wait constraints on some operations. On the other hand, skilled workers performing some manual tasks are modelled as special machines. The system produces approximate solutions in very short computing times, trying to minimiz…
GRASP and path relinking for project scheduling under partially renewable resources
2008
[EN] Recently, in the field of project scheduling problems the concept of partially renewable resources has been introduced. Theoretically, it is a generalization of both renewable and non-renewable resources. From an applied point of view, partially renewable resources allow us to model a large variety of situations that do not fit into classical models, but can be found in real problems in timetabling and labor scheduling. In this paper, we develop some preprocessing techniques and several heuristic algorithms for the problem. Preprocessing significantly reduces the dimension of the problems, therefore improving the efficiency of solution procedures. Heuristic algorithms based on GRASP an…